In vitro antibiotic susceptibilities of ocular bacteria isolates from the cornea and conjunctiva to moxifloxacin, gatifloxacin and other fluoroquinolones
نویسندگان
چکیده
Trabalho realizado no Departamento de Oftalmologia da Universidade Federal de São Paulo. 1 Prof(a). Titular do Departamento de Oftalmologia UNIFESP/EPM. 2 Médica do Departamento de Oftalmologia UNIFESP/ EPM. 3 Doutor pelo Departamento de Oftalmologia UNIFESP/ EPM. 4 Profa Afiliada do Departamento de Oftalmologia UNIFESP/EPM. 5 Livre Docente e Profa Afiliada do Departamento de Oftalmologia UNIFESP/EPM.
منابع مشابه
[In vitro antibiotic susceptibility to fluoroquinolones].
OBJECTIVE To determine the antibiotic susceptibility of bacteria recovered from cultures of ocular infections in the Fundación Oftalmológica de Santander - Clínica Carlos Ardila Lulle (FOSCAL). MATERIALS AND METHODS Retrospective descriptive study of a series of registries of cultures of samples from ocular surfaces and intraocular fluids from the OCULAB-FOSCAL laboratory in Floridablanca (Co...
متن کاملIntraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin
PURPOSE The objective of the study was to compare the intraocular penetration levels of the newer fluoroquinolones, moxifloxacin, gatifloxacin, and levofloxacin in the rabbit's cornea, aqueous humor, and conjunctiva after topical instillation. METHODS 0.5% moxifloxacin, 0.3% gatifloxacin, and 0.5% levofloxacin were instilled in random sequence in both eyes of nine New Zealand White rabbits at...
متن کاملMutations in the quinolone resistance determining region in Staphylococcus epidermidis recovered from conjunctiva and their association with susceptibility to various fluoroquinolones
BACKGROUND Staphylococcus epidermidis is one of the prominent pathogens in ocular infection. The prevalence of mutations in the quinolone resistance determining region (QRDR) area in S epidermidis isolated from the ocular surface and its association with fluoroquinolone resistance has not been fully elucidated. METHODS Mutations in the QRDR of gyrA, gyrB, parC, and parE genes of 138 isolates ...
متن کاملIn vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy
Moxifloxacin and gatifloxacin are fourth-generation fluoroquinolone antibiotics used in the clinic to prevent or treat ocular infections. Their pharmacokinetics in the cornea is usually measured from extracted ocular fluids or tissues, and in vivo direct measurement is difficult. In this study multiphoton microscopy (MPM), which is a 3D optical microscopic technique based on multiphoton fluores...
متن کاملIn vitro fluoroquinolone resistance in staphylococcal endophthalmitis isolates.
OBJECTIVE To evaluate the in vitro susceptibility and cross-resistance of gatifloxacin and moxifloxacin vs older fluoroquinolones among coagulase-negative staphylococci recovered from patients with clinical endophthalmitis. METHODS A combination of E tests and disk diffusion methods was used to determine in vitro susceptibility and cross-resistance for 111 coagulase-negative staphylococci iso...
متن کامل